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YU Feng, LIN Mu-sen, ZHANG Wei-dong. Inhibition of berberine on I Kr ,I Ks and I K1 in thyroxine induced cardiomyopathic guinea pig ventricular myocytes[J]. Journal of China Pharmaceutical University, 2009, 40(3): 244-249.
Citation: YU Feng, LIN Mu-sen, ZHANG Wei-dong. Inhibition of berberine on I Kr ,I Ks and I K1 in thyroxine induced cardiomyopathic guinea pig ventricular myocytes[J]. Journal of China Pharmaceutical University, 2009, 40(3): 244-249.

Inhibition of berberine on I Kr ,I Ks and I K1 in thyroxine induced cardiomyopathic guinea pig ventricular myocytes

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  • Aim :To study the effects of berberine(Ber) on the rapidly activating component(I Kr ),the slowly activating component(I Ks) of the delayed rectifier potassium current and the inward rectifier potassium current(I K1) in cardiomyopathic guinea pig ventricular myocytes. Methods :After guinea pigs were ip L-thyroxine 0.5 mg/kg for 10 d,their hearts were cardiomyopathic.Then whole cell patch-clamp recording technique was used to observe the effect of 30 μmol/L Ber on the I Kr ,I Ks and I K1in cardiomyopathic guinea pig ventricular myocytes. Results :In cardiomyopathic guinea pig ventricular myocytes,Ber 30 μmol/L markedly inhibited I Kr and I Ks by 22.8% and 29.5% at +10 mV and +80 mV,respectively.The effect of Ber on I Ks was greater than that on I Kr .Ber 30 μmol/L also inhibited the inward component of I K1 by 29.1% at+120 mV,but the reverse potential of I K1was unaffected.Ber(1- 300 μmol/L) was shown to inhibit I Kr and I Ks in a concentration-dependent manner.Their IC50 were 76.74 μmol/L and 55.37 μmol/L,respectively. Conclusion :Ber inhibited I Kr ,I Ks and I K1in cardiomyopathic guinea pig ventricular myocytes,which may be important in understanding the antiarrhythmic effects of this drug.

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