• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
MIAO You-pan, LI Ai-xiu, LIU Tao, WU Ke-zhu. Molecular designing strategies of anti-drug-resistant HIV-1 protease inhibitors[J]. Journal of China Pharmaceutical University, 2009, 40(3): 279-283.
Citation: MIAO You-pan, LI Ai-xiu, LIU Tao, WU Ke-zhu. Molecular designing strategies of anti-drug-resistant HIV-1 protease inhibitors[J]. Journal of China Pharmaceutical University, 2009, 40(3): 279-283.

Molecular designing strategies of anti-drug-resistant HIV-1 protease inhibitors

More Information
  • HIV-1 protease inhibitors play a very important role in AIDS chemotherapy,but with the rapid emergence of drug resistance as a result of the residue mutation of HIV-1 protease,developing effective protease inhibitors with superior activity against drug-resistant variants is becoming the research hotspot in AIDS drug design. Meanwhile,some molecular designing strategies of anti-drug-resistant HIV-1 protease inhibitors were put forward and applied to develop anti-AIDS drugs.The purpose of the research is introducing these molecular designing strategies to develop potent HIV-1 protease inhibitors to combat drug resistance,including substrate envelope hypothesis,strengthening the binding of inhibitors to HIV-1 protease and searching inhibitors acting in novel sites of HIV-1 protease.
  • Related Articles

    [1]HUANG Zhicheng, YE Liu, DU Yu, GU Hongfeng, GAO Fanyun, ZHU Qihua, XU Yungen. Design, synthesis and biological evaluation of PARP-1/PI3K dual-target inhibitors[J]. Journal of China Pharmaceutical University, 2023, 54(4): 450-460. DOI: 10.11665/j.issn.1000-5048.2023050301
    [2]LI Zhiyan, LIU Jie, LI Bingyan, JIANG Cheng. Design, synthesis and evaluation of peptidomimetics targeting the polo-box domain of polo-like kinase 1[J]. Journal of China Pharmaceutical University, 2020, 51(3): 287-294. DOI: 10.11665/j.issn.1000-5048.20200305
    [3]SHI Jinyu, BAI Ying, PENG Kewen, ZHANG Wenhui, ZHU Qihua, XU Yungen. Research progress of PARP-1 inhibitors in combination with other drugs to overcome drug resistance[J]. Journal of China Pharmaceutical University, 2019, 50(5): 523-530. DOI: 10.11665/j.issn.1000-5048.20190503
    [4]DU Wenyi, HU Jianping, ZUO Ke, LIU Wei, LIANG Li, DAI Tianyang. Molecular simulation study on the recognition between hydroxy isoindolin ketone derivatives and HIV-1 integrase[J]. Journal of China Pharmaceutical University, 2016, 47(5): 551-559. DOI: 10.11665/j.issn.1000-5048.20160508
    [5]YANG Qian, MA Qiujuan, WANG Xiaojian. Suggestions for secondary innovations and generic development for drugs from the perspective of patent — taking HIV protease inhibitor lopinavir as an example[J]. Journal of China Pharmaceutical University, 2015, 46(4): 499-503. DOI: 10.11665/j.issn.1000-5048.20150419
    [6]TU Guogang, WANG Jiaqi, XIONG Shengtao, KUANG Binhai, LI Shaohua. Molecular dynamics simulation of matrix metalloproteinases S′1 binding pocket[J]. Journal of China Pharmaceutical University, 2013, 44(3): 219-222. DOI: 10.11665/j.issn.1000-5048.20130306
    [7]JIANG Neng, JIANG Jian-qin, SHEN Jian-hua. Design,synthesis and in vitro activity of quinazolone glycine transporter-1 inhibitors[J]. Journal of China Pharmaceutical University, 2012, 43(3): 199-203.
    [8]DENG Lian-bai, LI Ai-xiu, JIN Yu-rui. Advances in the study on inhibitors of RNase H,a novel anti-HIV drug target[J]. Journal of China Pharmaceutical University, 2011, 42(6): 578-584.
    [9]Computer-aided design of the 10-23 deoxyribozyme targeting resistance gene mecR1[J]. Journal of China Pharmaceutical University, 2010, 41(4): 380-384.
    [10]Synthesis and Bioactivity of N,N''''-Bis-substituted Urea Derivatives as Novel Small Molecular Inhibitors of Cysteine Protease of Trypanosoma cruzi[J]. Journal of China Pharmaceutical University, 2003, (6): 10-14.

Catalog

    Article views (1439) PDF downloads (1160) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return