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AO Gui-zhen, ZHENG Li-ling, XU Guang-lin, LI Jing. Synthesis and anti-inflammatory activity of α-aryl-3，5-dimethoxyphenylpropenamides[J]. Journal of China Pharmaceutical University, 2009, 40(4): 302-305.
Citation: AO Gui-zhen, ZHENG Li-ling, XU Guang-lin, LI Jing. Synthesis and anti-inflammatory activity of α-aryl-3，5-dimethoxyphenylpropenamides[J]. Journal of China Pharmaceutical University, 2009, 40(4): 302-305.
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Synthesis and anti-inflammatory activity of α-aryl-3，5-dimethoxyphenylpropenamides

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  • Aim ：To search for new compounds with stronger anti-inflammatory activities and less gastrointestinal side effects. Methods ：2-(2，4-Dichlorophenyl)-3-(3，5-dimethoxyphenyl)- propenoic acid(I) was converted to amides(II).Their anti-inflammatory activities against xylene-induced mice ear swelling were evaluated. Results ：Twelve target compounds (II1-12) were synthesized，and their structures were confirmed by IR，1H NMR and HR-MS.II3 exhibited significant anti-inflammatory activity compared with CMC-Na(P<0.01) and aspirin(P<0.05). Conclusion ：Compound II3 deserves further investigation.
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