Synthesis and anti-inflammatory activity of α-aryl-3，5-dimethoxyphenylpropenamides

Aim ：To search for new compounds with stronger anti-inflammatory activities and less gastrointestinal side effects. Methods ：2-(2，4-Dichlorophenyl)-3-(3，5-dimethoxyphenyl)- propenoic acid(I) was converted to amides(II).Their anti-inflammatory activities against xylene-induced mice ear swelling were evaluated. Results ：Twelve target compounds (II_1-12) were synthesized，and their structures were confirmed by IR，¹H NMR and HR-MS.II₃ exhibited significant anti-inflammatory activity compared with CMC-Na(P<0.01) and aspirin(P<0.05). Conclusion ：Compound II₃ deserves further investigation.