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ZHONG Wen-yuan, CHEN Shun-fang, FAN Chun-lan, CUI Yong-chun. In vitro anti-HIV activity of ［Ln(Phen)2 (5-Fu)3 (NO3)］(NO3)2[J]. Journal of China Pharmaceutical University, 2009, 40(5): 445-447.
Citation: ZHONG Wen-yuan, CHEN Shun-fang, FAN Chun-lan, CUI Yong-chun. In vitro anti-HIV activity of ［Ln(Phen)2 (5-Fu)3 (NO3)］(NO3)2[J]. Journal of China Pharmaceutical University, 2009, 40(5): 445-447.
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In vitro anti-HIV activity of ［Ln(Phen)2 (5-Fu)3 (NO3)］(NO3)2

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  • Aim ：To study in vitro anti-HIV activities of ［Ln(Phen)2 (5-Fu)3 (NO3)］(NO3)2. Methods ：Seven kinds of ［Ln(Phen)2 (5-Fu)3 (NO3)］(NO3)2complexes (Ln=Y，La，Ce，Sm，Gd，Dy，Er；Phen=1，10-phenanthroline；5-Fu=fluorouracil) were tested for their potential anti-HIV activities.IC50 of the complexes on C8166 cells was assayed by colorimetric MTT.EC50 was determined through the inhibition of syncytia formation induced by H9/HIV-1IIIB.The therapeutic index (TI，IC50/EC50) were calculated and compared with that of azidothymidine (AZT). Results ：It was found that TI of ［La(Phen)2 (5-Fu)3 (NO3)］(NO3)2 and［Ce(Phen)2 (5-Fu)3 (NO3)］(NO3)2 were 68.03 and 33.13，respectively. Conclusion ：La or Ce doped complexes demonstrated in vitro anti-HIV activity.
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