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DING Yan-wei, LI Zuo-kui, ZHAO Hua, ZHANG Jian-xin, LI Bao-qiu. Toxicity of glufosfamide in Beagle dogs following intravenous injection[J]. Journal of China Pharmaceutical University, 2009, 40(6): 535-538.
Citation: DING Yan-wei, LI Zuo-kui, ZHAO Hua, ZHANG Jian-xin, LI Bao-qiu. Toxicity of glufosfamide in Beagle dogs following intravenous injection[J]. Journal of China Pharmaceutical University, 2009, 40(6): 535-538.

Toxicity of glufosfamide in Beagle dogs following intravenous injection

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  • Aim :To evaluate the safety of glufosfamide in Beagle dogs. Methods :The safety of glufosfamide in Beagle dogs following single iv and multiple iv administration for 3 months was observed. Results :The minimum lethal dose of glufosfamide was 100 mg/kg.The maximum non-lethal dose of glufosfamide was 50 mg/kg.The approximate lethal dose of glufosfamide was 75-100 mg/kg.No serious adverse reactions was observed in Beagle dogs following multiple iv administration once a week for 3 months at the dose of 20 mg/kg,40 mg/kg,and 60 mg/kg.However,organ injury was observed extensively in the high dose-group and mediumt-dose group.The low-dose group showed a light change in individual organs. Conclusion :Under the experimental conditions,40 mg/kg and 60 mg/kg iv administration once a week for 3 months can lead to extensive organ injury in Beagle dogs,so the dose shouldn′t be higher than 20 mg/kg.
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