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Synthesis and antitumor activity of ent-kaurene diterpenoids[J]. Journal of China Pharmaceutical University, 2010, 41(1): 20-25.
Citation: Synthesis and antitumor activity of ent-kaurene diterpenoids[J]. Journal of China Pharmaceutical University, 2010, 41(1): 20-25.

Synthesis and antitumor activity of ent-kaurene diterpenoids

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  • Aim: To synthesize the ent-kaurene diterpenoid and its derivatives from natural available stevioside. Methods: The crucial pharmacophore of exo-methylene ketone was designed and the carboxyl group at C-4 was modifiedThe cytotoxic inhibition activities in vitro of target compounds were evaluated against human cancer cells BEL-7402,HO-8910,MCF-7 and HL-60 by a MTT method. Results and Conclusion: The structures of new target compounds were identified by 1H NMR,FT-IR and EI-MS. The preliminary experimental results showed that some derivatives of ent-kaurene diterpenoid possessed fair inhibitory activity against tumor cell lines compared with that of their parent steviol.

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