• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
Effects of astragaloside IV on experimental ventricular remodeling in mice and its mechanism from matrix metalloproteinase aspect[J]. Journal of China Pharmaceutical University, 2010, 41(1): 70-75.
Citation: Effects of astragaloside IV on experimental ventricular remodeling in mice and its mechanism from matrix metalloproteinase aspect[J]. Journal of China Pharmaceutical University, 2010, 41(1): 70-75.

Effects of astragaloside IV on experimental ventricular remodeling in mice and its mechanism from matrix metalloproteinase aspect

More Information
  • Aim: To study the effects of astragaloside IV on experimental ventricular remodeling in mice and its mechanism from matrix metalloproteinase aspect. Method: Ventricular remodeling in mice was induced by consecutively subcutaneous injection of isoproterenol for 14 days.Astragaloside IV(40,80 mg/kg) and propranolol(40 mg/kg,positive control) were administered by gavage to mice.Echocardiography was used to observe the left ventricular end diastolic diameter(LVIDd),left ventricular end systolic diameter(LVIDs),fractional shortening(FS) and ejection fraction(EF).The myocardial pathological pattern was detected by HE staining.Expressions of matrix metalloproteinases(MMP2,MMP9) and tissue inhibitor of metalloproteinases(TIMP1,TIMP2) mRNA in myocardium were detected by RT-PCR.Activities of MMP2 and MMP9 were assayed by zymography. Results: Compared with those of control mice,LVIDd and LVIDs were increased,FS and EF were decreased in the model group.Myocardial injury and fibrosis existed in histop at hological slices of the model group.In addition,the mRNA expressions and activities of MMP2 and MMP9 were increased in the model group.However,there were no markable changes to TIMP1 and TIMP2.Treatment with astragaloside IV reduced LVIDd and LVIDs,increased FS and EF,attenuated myocardial injury,and down-regulated mRNA expressions and activities of MMP2 and MMP9 compared with the model group. Conclusion: Astragaloside IV can greatly improve ventricular remodeling and dysfunction via decreasing MMP2 and MMP9 mRNA expression and activities in cardiac ventricles.
  • Related Articles

    [1]ZHAO Xun, SHAO Fangxian, YUAN Yaozuo, ZHANG Mei, TAN Li. Determination of the related substances of benzyl hydroxybenzoate by RP-HPLC[J]. Journal of China Pharmaceutical University, 2017, 48(3): 317-321. DOI: 10.11665/j.issn.1000-5048.20170311
    [2]Studies on the HPLC Fingerprinting of Danshen Crude Drugs[J]. Journal of China Pharmaceutical University, 2002, (2): 49-52.
    [3]Determination of Nefopam in Plasma by HPLC[J]. Journal of China Pharmaceutical University, 2000, (5): 45-47.
    [4]HPLC Determination of Diclofenac in Transdermal Receiver Solution[J]. Journal of China Pharmaceutical University, 1994, (6): 342-344.
    [5]Determination of Sulthiame and Its Formulation by HPLC[J]. Journal of China Pharmaceutical University, 1993, (1): 58-59.
    [6]Determination of Methandienone and Its Metabolite in Human Urine by HPLC[J]. Journal of China Pharmaceutical University, 1991, (2): 83-85.
    [7]HPLC SIMULTANEOUS DETERMINATION OF PYRONARIDINE AND PRIMAQUIND IN PLASMA[J]. Journal of China Pharmaceutical University, 1989, (4): 240-242.
    [8]SIMULTANEOUS DETERMINATION OF CHLORAMPHENICAL AND ITS DEGRADATION PRODUCT IN OPHTHALMIC BY HPLC[J]. Journal of China Pharmaceutical University, 1988, (2): 138-140.
    [9]OPTIMIZATION OF HPLC SEPARATION OF NITROGLYCERIN FILMS BY SIMPLEX METHOD[J]. Journal of China Pharmaceutical University, 1986, (2): 146-148.
    [10]DETERMINATION OF GLYCERIN TRINITRATE AND ITS DEGRADATION PRODUCTS IN TABLETS AND EVALUATION OF THE STORAGE BY HPLC[J]. Journal of China Pharmaceutical University, 1986, (1): 46-51.

Catalog

    Article views PDF downloads Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return