Synthesis and anti-platelet aggregation activity of substituted (E)-1，2-diarylethene compounds

Based on the analysis of the structure of diethyl 2-bromobenzylphosphonate，a series of substituted (E)-1，2-diarylethene compounds V₁-V₉ ， VI₁-VI₄ ) were synthesized，and their anti-platelet aggregation activities were evaluated.Their structures were confirmed by ¹H NMR，IR and MS.It was found that most of the synthesized compounds possessed the anti-platelet aggregation activities，of which compounds V₄ and V₉ showed the most potent activities.Substituted(E)-1，2-diarylethene compounds are potentially new candidates as anti-platelet aggregation agents.〖