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XU Yu-ting, ZHANG Can. Synthesis and characterization of graft chitosan-mPEG copolymers by “click chemistry” reaction[J]. Journal of China Pharmaceutical University, 2010, 41(6): 481-486.
Citation: XU Yu-ting, ZHANG Can. Synthesis and characterization of graft chitosan-mPEG copolymers by “click chemistry” reaction[J]. Journal of China Pharmaceutical University, 2010, 41(6): 481-486.

Synthesis and characterization of graft chitosan-mPEG copolymers by “click chemistry” reaction

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  • The “click chemistry” reaction was used to solve the problem to remove excess PEG from graft chitosan-mPEG copolymers for synthesis.A series of graft chitosan-mPEG copolymers were first synthesized via “click chemistry” reaction between azido-end monomethoxypolyethylene glycol and alkynyl chitosans that were synthesized by N-alkylation of chitosans with propargyl bromide.The chemical structures of the copolymers were characterized by 1H NMR and FT-IR and their physical properties were measured by differential scanning calorimetry(DSC) and thermogravimetric analysis(TG).The graft rate of PEG in copolymers was determined to be about 11% with 1H NMR.The DSC analyses showed that the crystallinity of the copolymers decreased. The TG analyses proved that the thermal stability of the copolymers increased. The graft chitosan-mPEG copolymers may be used as drug carriers.
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