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GE Liang, LU Man, CHEN Yue-jian, CHEN Yan-hua. In vitro release and the liver targeting of oxymatrine polybutylcyanoacrylate nanoparticles[J]. Journal of China Pharmaceutical University, 2010, 41(6): 520-523.
Citation: GE Liang, LU Man, CHEN Yue-jian, CHEN Yan-hua. In vitro release and the liver targeting of oxymatrine polybutylcyanoacrylate nanoparticles[J]. Journal of China Pharmaceutical University, 2010, 41(6): 520-523.
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In vitro release and the liver targeting of oxymatrine polybutylcyanoacrylate nanoparticles

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  • Oxymatrine (OM) polybutylcyanoacrylate nanoparticles (OM-PBCA-NP) was prepared,and in vitro release of OM-PBCA-NP as well as the liver targeting potentials of OM-PBCA-NP and oxymatrine solution (OM-SOL) were studied in mice. It was found that 100% of OM was released from OM solution in 4 h,but only 36.73％ from OM-PBCA-NP. In the study of tissue distribution of OM-PBCA-NP,there existed 8.338-fold increase in the area under the liver concentration-time curve in comparison to that of OM-SOL. Hence,OM-PBCA-NP sustained drug release and increased the liver targeting significantly.
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