Development of in-vitro evaluation methods to access membrane permeability of drugs

Membrane permeability is one of the key properties which affect drug safety and efficacy,so its evaluation is very important for enhancing drug development efficiency and reducing drug reseach spendings. Recently,in-vitro evaluation methods have become the focus in the field of drug membrane permeability researches. In this paper,the developments of in-vitro evaluation methods are summarized,including two-phase partitioning method,chromatography method,capillary electrophoresis method,optical biosensor assay and parallel artificial membrane assay.