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YANG Jia-bin, CHEN Li, SU Guo-qiang, REN Yu. Synthesis and tubulin polymerization inhibitory activity of osthol stilbene derivatives[J]. Journal of China Pharmaceutical University, 2011, 42(2): 107-111.
Citation: YANG Jia-bin, CHEN Li, SU Guo-qiang, REN Yu. Synthesis and tubulin polymerization inhibitory activity of osthol stilbene derivatives[J]. Journal of China Pharmaceutical University, 2011, 42(2): 107-111.

Synthesis and tubulin polymerization inhibitory activity of osthol stilbene derivatives

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  • A series of novel osthole stilbene derivatives were synthesized,and their structures were determined by MS and 1H NMR.The tubulin polymerization inhibitory activity of the synthesized compounds was evaluated using anti-human umbilical vein endothelial cells in vitro.Preliminary results showed that compound 7 was the most potent inhibitor,but was less potent than combretastatin A-4.Compound 7 is a promising compound worthy of further studies.
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