Synthesis and tubulin polymerization inhibitory activity of osthol stilbene derivatives

A series of novel osthole stilbene derivatives were synthesized,and their structures were determined by MS and ¹H NMR.The tubulin polymerization inhibitory activity of the synthesized compounds was evaluated using anti-human umbilical vein endothelial cells in vitro.Preliminary results showed that compound Ⅵ₇ was the most potent inhibitor,but was less potent than combretastatin A-4.Compound Ⅵ_7 is a promising compound worthy of further studies.