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HUANG Yan-yu, MENG Ting, QU Guo-wei, ZHANG Can. Synthesis,characterization and properties as a drug carrier of the amphiphilic MPEG-PLA-β-CD[J]. Journal of China Pharmaceutical University, 2011, 42(4): 294-298.
Citation: HUANG Yan-yu, MENG Ting, QU Guo-wei, ZHANG Can. Synthesis,characterization and properties as a drug carrier of the amphiphilic MPEG-PLA-β-CD[J]. Journal of China Pharmaceutical University, 2011, 42(4): 294-298.
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Synthesis,characterization and properties as a drug carrier of the amphiphilic MPEG-PLA-β-CD

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  • A novel series of amphiphilic polymers,MPEG-PLA-β-CD,with different relative molecular weight were synthesized by conjugating MPEG-PLA onto 6-deoxy-6-ethylenediamino-β-cyclodextrin through succinic anhydrideas spacers.The chemical structures were characterized by FT-IR and 1H NMR.The critical micelle concentrations(CMCs) were determined by pyrene fluorescence probe spectrometry.These polymers could self-assemble into micelles loading hydrophobic drugs.Diameters,the drug-encapsulation efficiency and drug-loading efficiency of the micelles loading ibuprofen were also measured to investigate the properties of polymers as drug delivery systems.According to the results,MPEG 2K-PLA 6.6K-β-CD was a potential drug delivery agent owing to its lower CMC value and higher drug-loading efficiency.
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