• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
GAO Yuan, JIANG Kun, LI Li, XI Yi-feng. Bioavailability enhancement of baicalein by nanosuspension[J]. Journal of China Pharmaceutical University, 2011, 42(4): 314-318.
Citation: GAO Yuan, JIANG Kun, LI Li, XI Yi-feng. Bioavailability enhancement of baicalein by nanosuspension[J]. Journal of China Pharmaceutical University, 2011, 42(4): 314-318.

Bioavailability enhancement of baicalein by nanosuspension

More Information
  • Baicalein nanosuspension was prepared by antisolvent recrystalization method combined with subsequent homogenization.The oral bioavailability of baicalein nanosuspension in rats was also studied.The concentration of baicalin in rat plasma was determined by HPLC method.The pharmacokinetic parameters were calculated by DAS 2.0 software.It was found that the plasma drug concentration-time curves of baicalein all showed two peaks after oral administration.The cmax,tmaxand AUC0-24 h of the raw baicalein and baicalein nanosuspension was 7.18 and 11.12 μg/mL,1.67 and 0.92 h,71.40 and 118.63 μg·h/mL,respectively.Compared with baicalein bulk,the relative bioavailability of baicalein nanosuspension was 166.1%.Nanosuspension could significantly enhance the oral bioavailability of baicalein in rats.
  • Related Articles

    [1]Relative Bioavailability and Pharmacokinetics of Roxithromycin Dispersive Tablets in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 2004, (4): 41-43.
    [2]Pharmacokinetics and Bioavailability of Cinnamic Acid in Mice[J]. Journal of China Pharmaceutical University, 2004, (4): 38-40.
    [3]Relative Bioavailability of Oxcarbazepine Tablets in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 2004, (3): 50-53.
    [4]Pharmacokinetics and Relative Bioavailability of Medroxypro gesterone Capsules and Tablets in Healthy Male Volunteers[J]. Journal of China Pharmaceutical University, 2001, (6): 26-28.
    [5]Pharmacokinetics andRelative Bioavailability of Acyclovir Tablets in Men[J]. Journal of China Pharmaceutical University, 2001, (3): 52-54.
    [6]YANG Jing, DING Li, LI Fan, HUA Ya-Ping, WANG Guang-Ji. Pharmacokinetics of Soft Capsule of CoQ_(10) in Chinese Healthy Volunteers[J]. Journal of China Pharmaceutical University, 2001, (2).
    [7]Pharmacokinetics and Relative Bioavailability of Gliquidone Capsules and Tablets[J]. Journal of China Pharmaceutical University, 2000, (6): 19-21.
    [8]Pharmacokinetics and Relative Bioavailability of Cyclosporin Pearls in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 1996, (6): 20-22.
    [9]Pharmacokinetics and Relative Bioavailability of Tamoxifen in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 1995, (2): 84-86.
    [10]Pharmacokinetics and Bioavailability of Ribavirin in 9 Chinese Healthy Volunteers[J]. Journal of China Pharmaceutical University, 1994, (6): 325-327.

Catalog

    Article views (1479) PDF downloads (2436) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return