• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
ZHANG Guo-lin, XU Ming, DAI De-zai, XI Tao, DAI Yin. Endothelin-NADPH oxidase mediates cardiomyocytes dysfunction caused by H2O2 and interventions by CPU0213[J]. Journal of China Pharmaceutical University, 2011, 42(5): 452-457.
Citation: ZHANG Guo-lin, XU Ming, DAI De-zai, XI Tao, DAI Yin. Endothelin-NADPH oxidase mediates cardiomyocytes dysfunction caused by H2O2 and interventions by CPU0213[J]. Journal of China Pharmaceutical University, 2011, 42(5): 452-457.
shu

Endothelin-NADPH oxidase mediates cardiomyocytes dysfunction caused by H2O2 and interventions by CPU0213

More Information
    Graphical Abstract
    • Abstract
  • Over-activated NADPH oxidase and endothelin（ET）system are the main mechanism of cardiomyocytes dysfunction.This research mainly focuses on the hypothesis that CPU0213 attenuates cardiomyocytes dysfunction by inhibiting the over-expression of ET-NADPH oxidase.Cardiomyocytes were divided into groups:control, H2O2 group, H89/Bis, APO/DPI, CPU0213 group.The expression of FKBP12.6, SERCA2a and CASQ2 were down-regulated and pPKCε/PKCε，NADPH oxidase and ETAR/ETBR were up-regulated in H2O2 treated group,which implyed the involvement of PKCε.Endothelin receptor antagonist CPU0213 attenuated the abnormal expression of FKBP12.6, SERCA2a and CASQ2 by inhibiting pPKC-NADPH pathway.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]ZOU Qiao-gen, CUI Jia-hua, FENG Zhen-bin, WEI Ping. Separation of fenticonazole nitrate enantiomers by chiral-HPLC[J]. Journal of China Pharmaceutical University, 2011, 42(6): 534-537.
    [2]Establishment of HPLC for the Determination of Fluorouracil in Biological Sample s and Study on Its Pharmacokinetics in Mice[J]. Journal of China Pharmaceutical University, 2000, (6): 34-37.
    [3]Determination of Nefopam in Plasma by HPLC[J]. Journal of China Pharmaceutical University, 2000, (5): 45-47.
    [4]Determination of Meloxicamin Human Plasma by HPLC and Evaluation of Its Bioequivalence Assessment[J]. Journal of China Pharmaceutical University, 2000, (4): 31-34.
    [5]Bioequivalence Study of the Two Kinds of Ofloxacin Tablets in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 1998, (6): 433-436.
    [6]Bioequivalence of Doxofylline in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 1998, (5): 33-35.
    [7]HPLC Determination of Diclofenac in Transdermal Receiver Solution[J]. Journal of China Pharmaceutical University, 1994, (6): 342-344.
    [8]Determination of Sulthiame and Its Formulation by HPLC[J]. Journal of China Pharmaceutical University, 1993, (1): 58-59.
    [9]Derivative Chromatography Method for Identifying Purity of HPLC[J]. Journal of China Pharmaceutical University, 1991, (5): 295-298.
    [10]DEVELOPMENT AND PHARMACOKINETIC STUDY OF SUSTAINED RELEASE IBUPROFEN PELLETS[J]. Journal of China Pharmaceutical University, 1989, (5): 266-270.

Catalog

    Get Citation
    PDF
    XML
    Article views (1596) PDF downloads (1608) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：287845

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return