Synthesis and calcium channel blocking activities of dipiperazine compounds

With using flunarizine as a lead compund to search for calcium channel blockers with fewer side effects and improved potency,a series of dipiperazine compounds were prepared with their structures being confirmed by spectrometry.Their inhibitory effect on potential-dependent calcium channels(PDC) and Ca²⁺ antagonistic effect in rat aorta were determined by ⁴⁵Ca²⁺ transmembrane influx technique.Preliminary results showed that all the nine new compounds possessed calcium channel blocking activities.Some compounds exhibited stronger inhibitory effect on PDC than nifedipine.