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LI Si-wen, TIAN Jun-mei, JIN Jing, DU Chang-li, ZHAO Juan, GU Yue-qing. Targeted biodistribution of aminoglucose-modified doxorubicin[J]. Journal of China Pharmaceutical University, 2012, 43(3): 266-270.
Citation: LI Si-wen, TIAN Jun-mei, JIN Jing, DU Chang-li, ZHAO Juan, GU Yue-qing. Targeted biodistribution of aminoglucose-modified doxorubicin[J]. Journal of China Pharmaceutical University, 2012, 43(3): 266-270.
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Targeted biodistribution of aminoglucose-modified doxorubicin

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  • In order to improve in vivotargeting of doxorubicin (Dox) and reduce its toxicity,the targeting ligand 2-deoxy-aminoglucose (AG) was used to modify doxorubicin to form a new anti-tumor drug.The products were charactered by 1H NMR and MS,and the targeting was investigated by near-infrared imaging.Compared with Dox,the product treating MCF-7 and U87MG cells showed higher antitumor activity in vitro by MTT assay.In conclusion,the modified products effectively enhanced the targeting and pharmacodynamics in contrast with Dox,and it would be a potential therapeutic drug for cancer.
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