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LIU Haomiao, HU Xiaowen, ZHOU Jinpei, ZHANG Huibin. Advances of G protein coupled receptor 119 agonists and their structure-activity relationship[J]. Journal of China Pharmaceutical University, 2013, 44(1): 11-19. DOI: 10.11665/j.issn.1000-5048.20130102
Citation: LIU Haomiao, HU Xiaowen, ZHOU Jinpei, ZHANG Huibin. Advances of G protein coupled receptor 119 agonists and their structure-activity relationship[J]. Journal of China Pharmaceutical University, 2013, 44(1): 11-19. DOI: 10.11665/j.issn.1000-5048.20130102
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Advances of G protein coupled receptor 119 agonists and their structure-activity relationship

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  • G Protein Coupled Receptor 119 (GPR119),expressed primarily in the pancreas,liver and gastrointestinal tract,is a new target for the treatment of type 2 diabetes mellitus (T2DM).GPR119 agonists can rise the level of intracellular cAMP,leading to increased glucose-dependent insulin,GLP-1 (glucagon-like peptide 1) and GIP (gastric inhibitory peptide) secretion.Therefore,they play an important role in the treatment of T2DM.This review summarizes the research progress on the structure-activity relationships of GPR119 agonists from different pharmaceutical companies and introduced our efforts in this field.
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