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YANG Chunyu, HUANG Zhangjian, LING Jingjing, JI Hui, LAI Yisheng, XU Jinyi, PENG Sixun, ZHANG Yihua. Synthesis and evaluation of carbamate-isosorbide-3-n-butylphthalide ring opening derivative trihybrids as novel platelet aggregation inhibitors[J]. Journal of China Pharmaceutical University, 2013, 44(3): 202-206. DOI: 10.11665/j.issn.1000-5048.20130302
Citation: YANG Chunyu, HUANG Zhangjian, LING Jingjing, JI Hui, LAI Yisheng, XU Jinyi, PENG Sixun, ZHANG Yihua. Synthesis and evaluation of carbamate-isosorbide-3-n-butylphthalide ring opening derivative trihybrids as novel platelet aggregation inhibitors[J]. Journal of China Pharmaceutical University, 2013, 44(3): 202-206. DOI: 10.11665/j.issn.1000-5048.20130302
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Synthesis and evaluation of carbamate-isosorbide-3-n-butylphthalide ring opening derivative trihybrids as novel platelet aggregation inhibitors

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  • A series of carbamate-isosorbide-3-n-butylphthalide ring opening derivative trihybrids( 8a - 8i) were synthesized, and their structures were confirmed by 1H NMR and MS. The inhibitory activity of the target compounds against adenosine diphosphate(ADP)-induced platelet aggregation was evaluated in vitro by Born′s turbidimetric assay. In comparison with 3-n-butylphthalide(NBP), compound 8i possessed better antiplatelet aggregation activity and aqueous solubility. Therefore, compound 8i may be a potential platelet aggregation inhibitor for further investigation.
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