Synthesis and evaluation of carbamate-isosorbide-3-n-butylphthalide ring opening derivative trihybrids as novel platelet aggregation inhibitors

A series of carbamate-isosorbide-3-n-butylphthalide ring opening derivative trihybrids( 8a - 8i) were synthesized, and their structures were confirmed by ¹H NMR and MS. The inhibitory activity of the target compounds against adenosine diphosphate(ADP)-induced platelet aggregation was evaluated in vitro by Born′s turbidimetric assay. In comparison with 3-n-butylphthalide(NBP), compound 8i possessed better antiplatelet aggregation activity and aqueous solubility. Therefore, compound 8i may be a potential platelet aggregation inhibitor for further investigation.