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LI Chen, YUAN Linhua, MA Xueqin, LIU Xiaoquan, XI Tao. Variation of cardiovascular risk biomarkers in type 2 diabetes mellitus[J]. Journal of China Pharmaceutical University, 2013, 44(3): 257-262. DOI: 10.11665/j.issn.1000-5048.20130314
Citation: LI Chen, YUAN Linhua, MA Xueqin, LIU Xiaoquan, XI Tao. Variation of cardiovascular risk biomarkers in type 2 diabetes mellitus[J]. Journal of China Pharmaceutical University, 2013, 44(3): 257-262. DOI: 10.11665/j.issn.1000-5048.20130314
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Variation of cardiovascular risk biomarkers in type 2 diabetes mellitus

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  • The aim of study was to determine the relationship between the biomarker of glucose and lipid metabolism and NG, NG′-asymmetric dimethylarginine(ADMA), total homocysteine(tHcy), adiponectin(APN)and pentraxin 3(PTX3)in type 2 diabetes mellitus rats. Diabetes was induced in Sprague-Dawley rats by a single intraperitoneal injection of 35mg/kg streptozotocin(STZ). Before and 2nd, 4th, 7th, 9th weeks after STZ injection, fasting plasma glucose(FPG), fasting insulin(FINS), OGTT, serum lipid(TC, TG and LDL-C), ADMA, tHcy, APN, PTX3 were determined. Compared with the groups of control and high fat diet(HFD), FPG, Homeostasis model assessment for insulin resistence index(HOMA-IR), TC, TG and LDL-C level of type 2 diabetes mellitus(T2DM)groups were significantly increased. In T2DM group, the concentration of ADMA increased gradually, tHcy decreased by degrees, APN reduced significantly, the PTX3 elevated remarkably. Our results indicate that ADMA, tHcy, APN, PTX3 are well correlated with glucose and lipid metabolism biomarkers. The plurality of biomarkers mentioned before should be monitored to evaluate the cardiovascular risk of type 2 diabetes mellitus.
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