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LIU Congbiao, GUO Zhen, LI Biao, WANG Jincan, YIN Xianzhen, ZHUWeifeng, WANG Liuyi, ZHANG Jiwen. Investigation of microstructures of freeze-dried orally disintegrating tablets by synchrotron radiation X-ray computed microtomography[J]. Journal of China Pharmaceutical University, 2014, 45(1): 48-53. DOI: 10.11665/j.issn.1000-5048.20140108
Citation: LIU Congbiao, GUO Zhen, LI Biao, WANG Jincan, YIN Xianzhen, ZHUWeifeng, WANG Liuyi, ZHANG Jiwen. Investigation of microstructures of freeze-dried orally disintegrating tablets by synchrotron radiation X-ray computed microtomography[J]. Journal of China Pharmaceutical University, 2014, 45(1): 48-53. DOI: 10.11665/j.issn.1000-5048.20140108
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Investigation of microstructures of freeze-dried orally disintegrating tablets by synchrotron radiation X-ray computed microtomography

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  • Freeze-dried orally disintegrating tablets prepared by direct compression of the freezing powders under low-temperature were shown of different properties compared with molded freeze-dried orally disintegrating tablets. The aim of this study were to scan the interior microstructures of orally disintegrating tablets by synchrotron radiation X-ray computed microtomography(SR-μCT)and to reconstruct and characterize the three-dimensional structural models shown in the slice of the central section within tablets. By setting the threshold of gray value, the sub-structures of the orally disintegrating tablets were extracted and quantitatively analyzed by Image pro Analyzer 3D software. Disintegration time and frangibility of tablets were determined and compared to study the correlation between pharmaceutical properties and internal microstructures. The results indicated that internal microstructures of orally disintegrating tablets with different preparation processes and formulations varied markedly. Molded freeze-dried tablets had an integral net structure, while tablets made by direct compression had a loose clusters grainy one. The difference in the internal microstructures could well explain why freeze-dried orally disintegrating tablets made by direct compression would disintegrate fast in less than 5s. Different preparation processes and formulation could led to a variety of sub-structure sections, such as reticulation structure, compact enclosure, fragments and small particles, which was responsible for the macroscopic structural mechanical properties. In conclusion, the research showed that SR-μCT was powerful in providing insight into the internal microstructures, and the pharmaceutical properties of freeze-dried orally disintegrating tablets were directly related to the internal microstructures.
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  • [1]
    Gryczke A,Schminke S,Maniruzzaman M,et al.Development and evaluation of orally disintegrating tablets(ODTs)containing ibuprofen granules prepared by hot melt extrusion[J].Colloids Surf B Biointerfaces,2011,86(2):275-284.
    [2]
    Jaysukh JH,Dhaval AR,Kantilal RV,et al.Orally disintegrating tablets:a review[J].Trop J Pharm Res,2009,8(2):161-172.
    [3]
    Stange U,Führling C,Gieseler H,et al.Influence of non-water-soluble placebo pellets of different sizes on the characteristics of orally disintegrating tablets manufactured by freeze-drying[J].J Pharm Sci,2013,102(6):1 786-1 799.
    [4]
    Brniak W,Jachowicz R,Krupa A,et al.Evaluation of co-processed excipients used for direct compression of orally disintegrating tablets(ODT)using novel disintegration apparatus[J].Pharm Dev Technol,2013,18(2):464-474.
    [5]
    Makino T.Fast dissolving tablet and its production: US,5720974[P].1998-02-24[2013-11-07].
    [6]
    Kuno Y,Kojima M,Ando S,et al.Effect of preparation method on properties of orally disintegrating tablets made by phase transition[J].Int J Pharm,2008,355(1/2):87-92.
    [7]
    Basu B,Bagadiya A,Makwana S,et al.Formulation and evaluation of fast dissolving tablets of cinnarizine using superdisintegrant blends and subliming material[J].J Adv Pharm Technol Res,2011,2(4):266-273.
    [8]
    Wu Y,Wu CH,Mei XG,et al.Formulation and preparation of epirubicin hydrochloride long-circulating thermosensitive freeze-dried liposomes and the drug release mechanism in vitro[J].Bull Acad Mil Med Sci(军事医学科学院院刊),20l0,32(4):139-145.
    [9]
    Shukla D,Chakraborty S,Singh S,et al.Mouth dissolving tablets I:an overview of formulation technology[J].Sci Pharm,2009,77:309-326.
    [10]
    Sano S,Iwao Y,Kimura S,et al.Preparation and evaluation of swelling induced-orally disintegrating tablets by microwave irradiation[J].Int J Pharm,2011,416(1):252-9.
    [11]
    Qin Y,Fan CH,Huang Q,et al.Applications of large-scale scientific facility-synchrotron radiation light source in analytical chemistry for life science[J]. Sci China Chem(中国科学:化学),2010,40(1):22-30.
    [12]
    Liu RH,Yin XZ,Li HY,et al.Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction[J]. Int J Pharm,2013,445(1/2):125-133.
    [13]
    Bi Y,Sunada H,Yonezawa Y,et al.Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity[J]. Chem Pharm Bull,1996,44(11):2121-2127.
    [14]
    Shoukri RA,Ahmed IS,Shamma RN.In vitro and in vivo evaluation of nimesulide lyophilized orally disintegrating tablets[J]. Eur J Pharm Biopharm,2009,73(1):162-171.
    [15]
    Okuda Y,Irisawa Y,Okimoto K,et al.A new formulation for orally disintegrating tablets using a suspension spray-coating method[J]. Int J Pharm,2009,382(1/2):80-87.
    [16]
    Okuda Y,Irisawa Y,Okimoto K,et al.Further improvement of orally disintegrating tablets using micronized ethylcellulose[J]. Int J Pharm,2012,423(2):351-359.
    [17]
    Darkwah J,Smith G,Ermolina I,et al.A THz spectroscopy method for quantifying the degree of crystallinity in freeze-dried gelatin/amino acid mixtures:an application for the development of rapidly disintegrating tablets[J]. Int J Pharm,2013,455(1/2):357-364.
    [18]
    Yin XZ,Li HY,Liu RH,et al.Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets[J].J Pharm Pharmacol,2013,65(7):953-959.
    [19]
    Yang S,Yin XZ,Li HY,et al.Research progress on architecture of dosage forms using synchrotron radiation X-ray microtomography[P]. Chin Sci Bull(生命科学),2013,25(8):794-802.
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