Advances in pancreatic β-cell protective strategies

WANG Jing; LIU Hongxia; CAI Dongcheng; HE Chaoyong

doi:10.11665/j.issn.1000-5048.20200515

Journal of China Pharmaceutical University > 2020 > 51(5): 622-627. > DOI: 10.11665/j.issn.1000-5048.20200515

WANG Jing, LIU Hongxia, CAI Dongcheng, HE Chaoyong. Advances in pancreatic β-cell protective strategies[J]. Journal of China Pharmaceutical University, 2020, 51(5): 622-627. DOI: 10.11665/j.issn.1000-5048.20200515

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Advances in pancreatic β-cell protective strategies

Funds: This study was supported by National Natural Science Foundation of China (No. 81670425); and the Specially-Appointed Professors Program of Jiangsu Province (No.1170010014)

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Received Date: December 29, 2019
Revised Date: June 17, 2020

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Abstract

Abstract

Pancreatic β cells, the only cells in the body that can synthesize and secrete insulin, can be damaged by a variety of pathological factors. Increasing attention has been paid to the studies of protecting pancreatic β cells in the treatment of diabetes. In this review, we highlight the studies that focus on enhancement of islet β cell function, reduction of islet β cell apoptosis, increase of islet β cell number and induction of islet β cell differentiation, providing novel targets and therapeutic strategies for the treatment of diabetes.
- pancreatic β cell,
- insulin,
- diabetes,
- protective strategy,
- advances

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References

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