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QIAN Sijia, YIN Jun, YAO Wenbing, GAO Xiangdong. Research progress of breast cancer metabolic reprogramming and microenvironment remodeling[J]. Journal of China Pharmaceutical University, 2021, 52(2): 156-163. DOI: 10.11665/j.issn.1000-5048.20210203
Citation: QIAN Sijia, YIN Jun, YAO Wenbing, GAO Xiangdong. Research progress of breast cancer metabolic reprogramming and microenvironment remodeling[J]. Journal of China Pharmaceutical University, 2021, 52(2): 156-163. DOI: 10.11665/j.issn.1000-5048.20210203
shu

Research progress of breast cancer metabolic reprogramming and microenvironment remodeling

  • 1.

    Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009

  • 2.

    School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by the Innovation Team of the "Double-First Class" Disciplines of China Pharmaceutical University (No.CPU2018GF08)
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  • Received Date: December 18, 2020
  • Revised Date: January 17, 2021
    Graphical Abstract
    • Abstract
  • As numerous connections between oncogenic signalling pathways and metabolic activities emerge, the importance of metabolic reprogramming in cancer is being increasingly recognized. During tumorigenesis, breast cancer cells undergo metabolic reprogramming, which generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and fatty acid biosynthesis. The extension and functional importance of these metabolic alterations may diverge according to breast cancer subtypes.Besides, aberrant metabolism of breast cancer cells remodels tumor microenvironment, promoting cancer vascularization and inhibiting anti-tumor immunity, and thus accelerates tumor progression.This review addresses current knowledge on the metabolic reprogramming and breast cancer microenvironment, which provides some reference for the development of metabolic target drugs for each breast cancer subtype.
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    • References (71)
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