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YANG Jingru, MA Yuhong, HUANG Dechun, QIAN Hongliang, CHEN Wei. Progress of intelligent-responsive insulin delivery mediated by glucose oxidase[J]. Journal of China Pharmaceutical University, 2021, 52(6): 663-674. DOI: 10.11665/j.issn.1000-5048.20210603
Citation: YANG Jingru, MA Yuhong, HUANG Dechun, QIAN Hongliang, CHEN Wei. Progress of intelligent-responsive insulin delivery mediated by glucose oxidase[J]. Journal of China Pharmaceutical University, 2021, 52(6): 663-674. DOI: 10.11665/j.issn.1000-5048.20210603
shu

Progress of intelligent-responsive insulin delivery mediated by glucose oxidase

  • Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Natural Science Foundation of China (No.51973233)
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  • Received Date: August 07, 2021
  • Revised Date: October 25, 2021
    Graphical Abstract
    • Abstract
  • The delivery of exogenous insulin is very important for the treatment of type 1 and advanced type 2 diabetes.Traditional injectable administration is prone to cause hypoglycemia, while the intelligent insulin system has the advantages of safety, long-term effectiveness, and high responsiveness.Glucose oxidase (GOx) can consume O2 and catalyze glucose to produce gluconic acid and H2O2.Therefore, the O2 level, H2O2 content and pH of GOx system are closely related to the glucose level in the system.This review introduces the application of GOx in closed-loop insulin delivery systems at home and abroad in recent years, which can be divided into single response and multiple response of pH-response, hypoxia-response, and H2O2-response according to the mechanism.It also discusses the opportunities and challenge facing by the application of GOx in the future.
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    • References (63)
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