肺动脉高压发生机制及治疗药物的研究进展

基金项目: 国家自然科学基金资助项目(No.81072519)

Progress in pathogenesis and therapeutic drugs of pulmonary arterial hypertension

摘要: 肺动脉高压（PAH）是一种以肺血管阻力和肺动脉压力渐进性升高为特征，最终导致患者右心衰竭而死亡的疾病。本文综述了近年来有关PAH发生的细胞和分子机制及其治疗药物的研究进展。
- 肺动脉高压 /
- 病理特征 /
- 发生机制 /
- 分子机制 /
- 治疗药物
Abstract: Pulmonary arterial hypertension(PAH) is a progressive and fatal disease,characterized by elevated pulmonary vascular resistance and pulmonary arterial pressure,most often resulting in right-sided heart failure.The mechanisms of action,approved PAH therapies and the latest agents in late-stage clinical development were reviewed and described in this paper.
- pulmonary arterial hypertension /
- pathologic features /
- pathogenesis /
- molecular mechanism /
- therapeutic drugs