Synthesis,characterization and cytotoxicity of platinum(II) complexes with 2-methyl-2-substituted phenoxypropanoic acid as leaving ligands

以2-甲基-2-取代苯氧基丙酸为离去基团的铂(Ⅱ)配合物的合成、表征及细胞毒活性

摘要: A class of novel platinum(II) complexes with 2-methyl-2-substituted phenoxypropanoic acids as leaving ligands were designed and synthesized.All complexes were characterized by IR,1H NMR and ESI-MS spectra.The in vitro antiproliferative activities were tested by MTT assay against three human cancer cell lines,indicating that the complexes showed selective cytotoxicity to human gastric cancer cell lines (SGC-7901) with only weak antiproliferative activities were observed against human hepatocellular carcinoma cell line (HepG2) and human non-small cell lung cancer cell line (A549).

Abstract: 设计合成了一系列以2-甲基-2-取代苯氧基丙酸为离去基团的二价铂配合物，其结构经红外光谱、核磁和质谱确证。采用MTT法对3种肿瘤细胞进行抗增殖活性研究，结果显示化合物对胃癌细胞(SGC-7901)活性较好，对肝癌细胞(HepG2)和非小细胞肺癌细胞(A549)活性较弱或无活性。