云南黄连中非生物碱类化学成分的研究

孟凡成; 王磊; 张健; 殷志琦; 张庆文; 叶文才

doi:10.11665/j.issn.1000-5048.20130404

云南黄连中非生物碱类化学成分的研究

Non-alkaloid chemical constituents from the rhizome of Coptis teeta

摘要

摘要: 对黄连属植物云南黄连Coptis teeta wall.根茎的乙醇提取物进行反复硅胶、凝胶、反相柱色谱和制备型高效液相色谱分离纯化，运用波谱学方法鉴定了12个化合物，分别为3，5，7-三羟基-6，8-二甲基黄酮(3，5，7-trihydroxy-6，8-dimethylflavone， 1 )，阿魏酸(ferulic acid， 2 )，Z-咖啡酸硬脂醇酯(Z-octadecyl caffeate， 3 )，原儿茶酸(protocatechuic acid， 4 )，丹参素甲酯(methyl-3，4-dihydroxyphenyl lactate， 5 )，3，4-二羟基苯乙醇(3，4-dihydroxy phenethyl alcohol， 6 )，3，5-dihydroxyphenethyl alcohol-3-O-β-D-glucopyranoside( 7 )，(+)-落叶松树脂醇［(+)-lariciresinol， 8 ］，woorenoside Ⅰ( 9 ) ，woorenoside Ⅱ( 10 )，longifolroside A( 11 )，(+)-syringaresinol-4-O-β-D-glucopyranoside( 12 )。所有化合物均为首次从云南黄连中得到，其中化合物 1 ， 4 ， 7 ， 11 首次从该属植物中得到。

Abstract: Twelve compounds were isolated and purified from the ethanol extract of Coptis teeta wall by various chromatographic methods, and their structures were elucidated by spectral techniques and physicochemical properties as 3, 5, 7-trihydroxy- 6, 8-dimethylflavone( 1 ), ferulic acid( 2 ), Z-octadecyl caffeate( 3 ), protocatechuic acid( 4 ), methyl-3, 4-dihydroxyphenyl lactate( 5 ), 3, 4-dihydroxyphenethyl alcohol( 6 ), 3, 5-dihydroxyphenethyl alcohol-3-O-β-D-glucopyranoside( 7 ), (+)-lariciresinol( 8 ), woorenoside I( 9) , woorenoside II( 10 ), longifolroside A( 11 )and(+)-syringaresinol-4-O-β-D-glucopyranoside( 12 ). Compounds 1 , 4 , 7 , 11 were isolated from this genus for the first time. All the compounds were isolated from this plant for the first time.

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