藤黄中三萜成分的研究

赵丽丽; 柳文媛; 王磊; 周爱南; 冯锋

doi:10.11665/j.issn.1000-5048.20140307

藤黄中三萜成分的研究

1.
中国药科大学天然药物化学教研室
2.
中国药科大学药物分析教研室
3.
中国药科大学生药学研究室
4.
上海医药工业研究院化学制药新技术中心

基金项目: 国家高技术研究发展计划(“八六三”计划)资助项目(No.2004AA2Z3A10)；高等学校博士学科点专项科研基金资助项目(No.20100096120005)

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- 刊出日期: 2014-06-24

Triterpenes from Garcinia hanburyi Hook.f.

摘要

摘要: 采用正相、反相硅胶柱色谱法和半制备型高效液相色谱法对中药藤黄(Garcinia hanburyi Hook.f)中的三萜类化合物进行了分离和纯化，通过NMR谱鉴定共得到10个化学成分:白桦脂酸( 1 )、α-香树精( 2 )、羽扇豆醇( 3 )、 β-香树素( 4 )、麦珠子酸( 5 )、蒲公英甾醇( 6 )、鲍尔烯醇( 7 )、丁酰鲸鱼醇( 8 )、3-O-α-L-吡喃阿拉伯糖齐墩果酸( 9 )和山楂酸( 10 )。其中，化合物 3 和 4 为首次从该植物中得到，化合物 5~10 为首次从该属植物中分离得到。
- 藤黄 /
- 化学成分 /
- 三萜 /
- 结构鉴定
Abstract: Ten triterpenes were isolated from Garcinia hanburyi Hook. f. by silica gel, reversed-phase silica gel column chromatography and semi-preparative high performance liquid chromatography. They were identified as betulinic acid( 1 ), α-amyrin( 2 ), lupeol( 3 ), β-amyrin( 4 ), alphitolic acid( 5 ), taraxasterol( 6 ), bauerenol( 7 ), butyrospermol( 8 ), 3-O-α-L-arabinopyranosyl oleanolic acid( 9 )and maslinic acid( 10 ). Compounds 3 and 4 were isolated from this plant for the first time, and compounds 5-10 were isolated from this genus for the first time.
- Garcinia hanburyi Hook.f. /
- chemical constituents /
- triterpenes /
- structural identification

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参考文献(15)

[1]	Sukpondma Y,Rukachaisirkul V,Phongpaichit S.Antibacterial caged-tetraprenylated xanthones from the fruits of Garcinia hanburyi[J].Chem Pharm Bull,2005,53(7):850-852.
[2]	Wang LL,Li ZL,Song DD,et al.Two novel triterpenoids with antiproliferative and apoptotic activities in human leukemia cells isolated from the resin of Garcinia hanburyi[J].Planta Med,2008,74(14):1 735-1 740.
[3]	Cui HY,Liu WY,Feng F,et al.Xanthone compounds isolated from Garcinia hanburyi and the related analytical methods:a review[J].Prog Pharm Sci(药学进展),2011,35(8):337-344.
[4]	Bi Y,Xu JY,Wu XM,Advance in research of betulinic acids[J].Chin J New Drugs(中国新药杂志). 2005,14(1):23-26.
[5]	He LQ,Wu YX,Fu L,et al.Synthesis and biological evaluation of aminoalcohol gambogate as anti-tumor agents[J].J China Pharm Univ(中国药科大学学报),2013,44(5):394-400.
[6]	Lin XJ,Liu JH,Qin MJ,et al.Chemical constituents from the bark of Platanus acerifolia Wild[J].J China Pharm Univ(中国药科大学学报),2013,44(3):210-212.
[7]	Li JJ,Wang AL,Yuan ZZ,et al.Triterpene compounds of Ainsliaea yunnanensis[J].Chin J Chin Mater Med(中国中药杂志),2013,38(22):3 918-3 922.
[8]	Se CK,Sue YL,Yoon-Jae S.Lupeol is one of active components in the extract of Chrysanthemum indicum Linne that inhibits LMP1-induced NF-κB activation[J].PLoS One,2013,8(11):e 82688.
[9]	Ragasa CA,Cornelio KB,Triterpenes from Euphorbia hirta and their cytotoxicity[J].Chin J Nat Med,2013,11(5):528-533.
[10]	Aguirre MC,Delporte C,Backhouse N,et al.Topical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae[J].Bioorg Med Chem,2006,14(16):5 673-5 677.
[11]	Wang B,Yang LY,Li GQ,et al.Antitum or Triterpenes from Scorzonera mongolica Maxin[J].Chin Pham J(中国药学杂志),2010,45(10):727-732.
[12]	Cerda-Garcia-Rojas CM,Hernandez-Vidal HH,Joseph-Nathan P.¹³C NMR assignments of D:C-friedours-7-ene derivatives.Evidence of an abnormal methyl group chemical shift[J].Magn Reson Chem,1996,34(10):777-781.
[13]	Tang T,Na Z,Xu YK.Chemical constituents from Dysoxylum lenticellatum[J].Chin Tradit Herb Drugs(中草药),2012,43(1):38-42.
[14]	Sha Y,Yan MC,Liu J,et al. Facile synthesis of oleanolic acid monoglycosides and diglycosides[J].Molecules,2008,13(7):1 472-1 486.
[15]	Lv H,Chen J,Li WL,et al.Studies on the triterpenes from loquat leaf(Eriobotrya japonica)[J].J Chin Med Mater(中药材),2008,31(9):1 351-1 354.

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藤黄中三萜成分的研究

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Triterpenes from Garcinia hanburyi Hook.f.

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