肿瘤CD44受体靶向及pH敏感寡聚透明质酸-缩酮载体的制备及表征

Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier

摘要: 利用组氨酸将母体材料寡聚透明质酸和pH敏感材料薄荷缩酮连接，制备了具有pH敏感和CD44受体靶向的寡聚透明质酸-缩酮载体，用¹H NMR和ESI-MS进行结构表征，并初步考察了寡聚透明质酸-缩酮载体材料胶束的制备、电镜形貌特征及pH敏感特性。结果表明，合成了两亲性的寡聚透明质酸-缩酮载体，在水中可自组装形成胶束，电镜形态为类球形，粒径100 nm左右，并且具有一定pH敏感性。因此，寡聚透明质酸-缩酮可作为新型CD44受体及pH敏感肿瘤靶向载体。

Abstract: Oligomeric hyaluronic acid(oHA)and ketal was linked by histidine to form a novel oHA-ketal(oHM)carrier with targeting capacity to CD44 receptor and pH sensitivity. The chemical structure of oHM was characterized by ¹H NMR and ESI-MS. Some properties, including the formation of micelles, morphology and pH-sensitivity were studied. The oHM can form micelles by self-assembly. The micelles were spherical shape with the diameter about 100 nm, and they also showed some pH-sensitivity. Therefore, oHM could be a potential pH-sensitive tumor targeting carrier to CD44 receptor.