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渗透泵给药系统的研究进展

马磊

马磊. 渗透泵给药系统的研究进展[J]. 中国药科大学学报, 2014, 45(6): 726-730. DOI: 10.11665/j.issn.1000-5048.20140620
引用本文: 马磊. 渗透泵给药系统的研究进展[J]. 中国药科大学学报, 2014, 45(6): 726-730. DOI: 10.11665/j.issn.1000-5048.20140620
MA Lei. Progress in osmotic pump drug delivery system[J]. Journal of China Pharmaceutical University, 2014, 45(6): 726-730. DOI: 10.11665/j.issn.1000-5048.20140620
Citation: MA Lei. Progress in osmotic pump drug delivery system[J]. Journal of China Pharmaceutical University, 2014, 45(6): 726-730. DOI: 10.11665/j.issn.1000-5048.20140620

渗透泵给药系统的研究进展

基金项目: 国家“重大新药创制”科技重大专项资助项目(No.2014ZX09507004)

Progress in osmotic pump drug delivery system

  • 摘要: 渗透泵给药系统可以实现药物的恒速释放,同时药物释放不受胃肠道pH及胃肠道蠕动的影响,具有良好的体内外相关性。此外,渗透泵制剂可以实现药物的持续释放,并降低血药浓度波动,从而降低药物的毒副作用。对于半衰期短的药物,渗透泵制剂可以提高药物疗效并降低毒性。因此,渗透泵制剂受到药物制剂工作者的广泛关注。本文通过查阅近几年国内外关于口服渗透泵给药系统的相关文献,介绍了现在国内外新型渗透泵制剂的研究现状,包括微孔渗透泵、夹层渗透泵、胃滞留型渗透泵、皮下埋植型纳米自乳化型渗透泵等多种新型给药系统,为渗透泵给药系统的研究与设计提供参考。
    Abstract: Osmotic pump drug delivery system(OPDDS)can obtain an extended drug release at zero-order rate. The release condition is not influenced by the gastric pH and hydrodynamic conditions of the body and exhibits good in vitro-in vivo correlation. Additionally, it can significantly reduce drug administration to one time a day and decrease the fluctuation of drug concentration in plasma, achieving better patient compliance and adherence. Besides, it can improve the therapeutic efficiency of drugs with short biological half-lives, reducing or eliminating the side-effects. Therefore, the OPDDS is a focus of pharmaceutics research. In this article, new progresses in the research of osmotic pump preparations, such as micro-porous osmotic pump drug delivery system, sandwiched osmotic pump drug delivery system, gastric-resident osmotic pump drug delivery system, subcutaneous osmotic pump drug delivery system, are reviewed for the pharmaceutical researchers to design and develop new osmotic pump delivery systems.
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出版历程
  • 刊出日期:  2014-12-24

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