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刘超, 钟惺, 席艳琼, 汤银霞, 蒋礼, 王福军, 蒲通, 曾苏. RP-HPLC测定替诺福韦及其有关物质[J]. 中国药科大学学报, 2015, 46(1): 78-80. DOI: 10.11665/j.issn.1000-5048.20150110
引用本文: 刘超, 钟惺, 席艳琼, 汤银霞, 蒋礼, 王福军, 蒲通, 曾苏. RP-HPLC测定替诺福韦及其有关物质[J]. 中国药科大学学报, 2015, 46(1): 78-80. DOI: 10.11665/j.issn.1000-5048.20150110
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LIU Chao, ZHONG Xing, XI Yanqiong, TANG Yinxia, JIANG Li, WANG Fujun, PU Tong, ZENG Su. Determination of the related substances of tenofovir by RP-HPLC[J]. Journal of China Pharmaceutical University, 2015, 46(1): 78-80. DOI: 10.11665/j.issn.1000-5048.20150110
Citation: LIU Chao, ZHONG Xing, XI Yanqiong, TANG Yinxia, JIANG Li, WANG Fujun, PU Tong, ZENG Su. Determination of the related substances of tenofovir by RP-HPLC[J]. Journal of China Pharmaceutical University, 2015, 46(1): 78-80. DOI: 10.11665/j.issn.1000-5048.20150110
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RP-HPLC测定替诺福韦及其有关物质

Determination of the related substances of tenofovir by RP-HPLC

    摘要
  • 摘要: 为了研究替诺福韦的有关物质，合成了3个有关化合物，建立了替诺福韦RP-HPLC分离条件(以Agilent ZORBAX SB-C18为色谱柱，以甲醇-0.02 mol/L磷酸二氢钾为流动相梯度洗脱，检测波长为260 nm)。结果显示替诺福韦有3种潜在的有关物质。所建立的分析方法准确度高，重复性好，适用于替诺福韦有关物质的含量检测。

     

    Abstract: To investigate the related substances of tenofovir, 3 related substances were synthesized. RP-HPLC analytical method was developed using Agilent ZORBAX SB-C18 column. The mobile phase composed of methanol and 0. 02 mol/L potassium dihydrogen phosphate. Linear gradient elution was used and the detection wavelength was 260 nm. 3 impurities were found in tenofovir. The established method was accurate and reproducible, and it can be applied for the related substances test in tenofovir.

     

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