Abstract:
This study was to investigate the protective effects of
Jinqi Jiangtang tablets on diabetic complications of cardiovascular disease in
Drosophila. The effects of
Jinqi Jiangtang tablets on hypolipidemia and hypoglycemia by high fat diet(HFD)induced model organism
Drosophila with the content of triglyceride and trehalose in
Drosophila as indexes, were investigated. And the
Drosophila heart function was detected by high speed EM-CCD; cell signaling pathways were detected by Western blot and RT-PCR. The results showed that high fat diet could induce the appearance of hyperglycemia and hyperlipidemia on
Drosophila model.
Jinqi Jiangtang tablets could significantly reduce triglyceride and trehalose and protect heart function of
Drosophila induced by high fat diet.
Jinqi Jiangtang tablets could also increase the expression of 4
ebp mRNA, while decreasing p-4EBP protein and
pepck mRNA expression. This study demonstrated that
Jinqi Jiangtang tablets have a protective effect on HFD-induced dyslipidemic-diabetic and cardiac dysfunction, which may be related to mTOR/4EBP pathway.