油酸及单硝酸异山梨酯载入量对单油酸甘油酯液晶体系相图及体外释放的影响

Effect of oleic acid and isosorbide mononitrate loading on the phase diagrams and in vitro release profiles of glyceryl monooleate liquid crystalline system

摘要: 考察油酸(OA)及单硝酸异山梨酯(ISMN)载入量对单油酸甘油酯(GMO)液晶体系相图及药物释放的影响。制备GMO/H₂O，GMO/H₂O/ISMN和GMO/H₂O/OA 3种液晶体系的相图，考察了GMO的吸水行为及ISMN从GMO液晶载药体系的释药特性。结果表明，药物从GMO中的释放属于扩散释放，ISMN载入量的升高加快液晶体系的释药速率，而油酸载入量的增加使释药减慢。本研究为GMO液晶体系的载药及附加剂的使用提供了理论基础。

Abstract: The aim of the study was to investigate the effect of oleic acid(OA)and isosorbide mononitrate(ISMN)on the phase diagrams of glyceryl monooleate(GMO)liquid crystalline systems and release of ISMN from them. Liquid crystalline systems of GMO/H₂O, GMO/H₂O/ISMN and GMO/H₂O/OA were prepared and their phase diagrams were plotted. Investigation of water absorption of GMO and ISMN release profiles shown that the release mechanism of ISMN was diffusion-controlled. Increased drug loading accelerated the release rate. However, the increased loading of OA decreased ISMN release. The result could offer practical basis for drug loading and the selection of additives in GMO liquid crystalline system.