香椿树皮的亲脂性成分研究

Lipophilic constituents from the stem bark of Toona sinensis

摘要: 采用硅胶、反相、凝胶柱色谱和制备薄层色谱等方法对香椿树皮95%乙醇提取物进行分离纯化，共得到10个化合物，应用光谱技术和理化常数对照等方法对其结构进行鉴定，分别为白桦脂酸( 1 )，豆甾烷-3，6-二酮( 2 )，豆甾-4-烯-3-酮( 3 )，7β-羟基谷甾醇( 4 )，6-羟基豆甾-4-烯-3-酮( 5 )，豆甾-4- 烯-3β，6β-二醇( 6 )，过氧化麦角甾醇( 7 )，7-methoxy-2-(3，4-methylenedioxyphenyl)benzofuran-5-carboxylat( 8 )，铁屎米-6-酮( 9 )，α-acetylamino-phenylpropyl α-benzoylamino phenylpropionate( 10 )。所有化合物均为首次从该植物中分离得到。

Abstract: Ten compounds were isolated from the 95% ethanol extract of the stem bark of Toona sinensis by silica gel, ODS Sephadex LH-20 column chromatographies and preparation TLC methods. Their structures were elucidated by spectroscopic methods and chemical properties as betulinic acid( 1 ), stigmastane-3, 6-dione( 2 ), stigmast-4-en-3-one( 3 ), 7β-hydroxysitosterol( 4 ), 6-hydroxystigmast-4-en-3-one( 5 ), stigmast-4-ene-3β, 6β-diol( 6 ), ergosterol peroxide( 7 ), 7-methoxy-2-(3, 4-methylenedioxyphenyl)benzofuran-5-carboxylate( 8 ), canthin-6-one( 9 ), and α-acetylamino-phenylpropyl α-benzoylamino phenylpropionate( 10 ). All compounds were isolated from T. sinensis for the first time.