Abstract: MicroRNA(miRNA), sharing the character of regulating the transcriptional level and expression level of mRNAs, is one kind of small non-coded RNAs. At present, innate immune has become one of the hot topics for researchers, and miRNAs as a sort of bioactive substance greatly take part in the whole regulation progress. In detailed, miRNAs can influence the immune state of immune cells during innate immune period and further regulate inflammatory conditions in whole body. By systematically summarizing miRNA function during innate immunity, this present review may provide a reference for peer researchers.