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杨蕊, 朱奕, 王颖, 马文琪, 王鑫, 韩熙琼, 刘乃丰. 自噬与血管钙化的研究进展[J]. 中国药科大学学报, 2018, 49(4): 401-406. DOI: 10.11665/j.issn.1000-5048.20180403
引用本文: 杨蕊, 朱奕, 王颖, 马文琪, 王鑫, 韩熙琼, 刘乃丰. 自噬与血管钙化的研究进展[J]. 中国药科大学学报, 2018, 49(4): 401-406. DOI: 10.11665/j.issn.1000-5048.20180403
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YANG Rui, ZHU Yi, WANG Yin, MA Wenqi, WANG Xin, HAN Xiqiong, LIU Naifeng. Recent progress in autophagy and vascular calcification[J]. Journal of China Pharmaceutical University, 2018, 49(4): 401-406. DOI: 10.11665/j.issn.1000-5048.20180403
Citation: YANG Rui, ZHU Yi, WANG Yin, MA Wenqi, WANG Xin, HAN Xiqiong, LIU Naifeng. Recent progress in autophagy and vascular calcification[J]. Journal of China Pharmaceutical University, 2018, 49(4): 401-406. DOI: 10.11665/j.issn.1000-5048.20180403
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自噬与血管钙化的研究进展

Recent progress in autophagy and vascular calcification

    摘要
  • 摘要: 自噬是真核细胞利用溶酶体对细胞器及蛋白质进行降解的“自我吞噬”生物学过程，近年来多项研究结果表明自噬在调控血管钙化中具有重要的作用。本文归纳了近年来与血管钙化进程中细胞自噬相关的研究，讨论了电解质失衡、基质囊泡释放、氧化应激、血管内皮炎症反应以及脂质代谢在自噬调节过程中所发挥的作用，对β-catenin/AMPK/CREB/Nrf2-ARE/Erα等信号转导通路在自噬诱导中的研究进展进行了综述。

     

    Abstract: Autophagy is a “self-devouring” biological process of the degradation of organelles and proteins by lysosomes in eukaryotic cells. In the past few years, some results revealed that autophagy played an important role in the regulation of vascular calcification. This review summarized the recent studies on autophagy in the process of vascular calcification, and discussed the effects of electrolyte imbalance, matrix vesicle release, oxidative stress, inflammatory reaction of vascular endothelial cells, and lipid metabolism in autophagy. The research progress of β-catenin/AMPK/CREB/Nrf2-ARE/Erα signal transduction pathways in autophagy induction was reviewed.

     

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