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Nrf2激活剂在阿尔茨海默病治疗中的应用

吴钰凤, 徐莉莉, 狄斌, 李博

吴钰凤, 徐莉莉, 狄斌, 李博. Nrf2激活剂在阿尔茨海默病治疗中的应用[J]. 中国药科大学学报, 2019, 50(6): 648-658. DOI: 10.11665/j.issn.1000-5048.20190603
引用本文: 吴钰凤, 徐莉莉, 狄斌, 李博. Nrf2激活剂在阿尔茨海默病治疗中的应用[J]. 中国药科大学学报, 2019, 50(6): 648-658. DOI: 10.11665/j.issn.1000-5048.20190603
shu
WU Yufeng, XU Lili, DI Bin, LI Bo. Application of Nrf2 activators in the treatment of Alzheimer′s disease[J]. Journal of China Pharmaceutical University, 2019, 50(6): 648-658. DOI: 10.11665/j.issn.1000-5048.20190603
Citation: WU Yufeng, XU Lili, DI Bin, LI Bo. Application of Nrf2 activators in the treatment of Alzheimer′s disease[J]. Journal of China Pharmaceutical University, 2019, 50(6): 648-658. DOI: 10.11665/j.issn.1000-5048.20190603
shu

Nrf2激活剂在阿尔茨海默病治疗中的应用

  • 中国药科大学药物分析系，蛋白质化学与结构生物学重点实验室

基金项目: 国家自然科学基金资助项目(No.81202491,No.81773693)；中央高校基本科研业务费专项资金资助项目(No.2632017ZD07)

Application of Nrf2 activators in the treatment of Alzheimer′s disease

摘要

    摘要
  • 摘要: 阿尔茨海默病是一种不可逆的神经退行性疾病，以细胞外老年斑(SP)中β淀粉样蛋白的异常沉积、tau蛋白过度磷酸化形成的细胞内神经原纤维缠结(NFT)为特征，病因尚不明确，氧化应激被认为是导致AD发生发展的重要因素。Keap1-Nrf2-ARE信号通路是机体抗氧化和/或亲电应激的最重要的防御机制之一，激活此通路可诱导一系列细胞保护基因的转录，减少氧化应激，发挥神经保护作用。本文概述了黄酮类、酚类、羧酸类、酯类及其他类Nrf2激活剂对阿尔茨海默病的治疗作用。
    Abstract: Alzheimer′s disease(AD)is an irreversible neurodegenerative disease. Main features in AD brains are abnormal deposition of amyloid-beta peptide(Aβ)in extracellular senile plaques(SP), intracellular neurofibrillary tangles(NFT)formed by hyperphosphorylated tau. The cause of AD is not clear. Oxidative stress is considered to be an important factor leading to the development of AD. Keap1-Nrf2-ARE signaling pathway is one of the most important defense mechanisms of antioxidant and/or electrophilic stress in the body. The activation of Keap1-Nrf2-ARE signaling pathway induces the transcription of a range of cytoprotective genes and reduces oxidative stress. This article outlines the therapeutic effect of flavonoids, phenols, carboxylic acids, esters and other Nrf2 activators on Alzheimer′s disease.
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