基质金属蛋白酶在疾病诊断中的应用及其检测方法

Clinical application and detection of matrix metalloproteinases in diagnosis

摘要: 近年来，随着对基质金属蛋白酶与疾病关系的研究逐渐深入，越来越多的研究发现基质金属蛋白酶与多种疾病的严重程度、诊断和预后等密切相关。因此基质金属蛋白酶作为一种非常有潜力的生物标志物得到了越来越多的关注。本文总结了基质金属蛋白酶在肿瘤、心血管疾病、炎症性疾病和神经退行性疾病等疾病诊断中的应用，并对基于RNA水平、蛋白质水平和MMPs的水解酶活性的3类检测方法进行了介绍，以期为基质金属蛋白酶检测的临床应用提供理论参考。

Abstract: Recently,an increasing number of studies have found that matrix metalloproteinase (MMPs) are closely related to the severity,diagnosis and prognosis of a variety of diseases. MMPs have therefore also gained increasing attention as a potential biomarker. In this paper,the application of MMPs in the diagnosis of tumors,cardiovascular diseases,inflammatory diseases and neurodegenerative diseases was summarized,and three types of detection methods based on RNA level,protein level and hydrolase activity of MMPs were introduced,which aims to provide some theoretical reference for the study of clinical application of MMPs detection.