Abstract: This paper using ESI,JCR,InCites,and WoS database,the data of Pharmacology and Toxicology were retrieved,and the development status of domestic universities was analyzed by using bibliometrics,statistics and other analysis methods. Taking Chinese universities ranked in the top 100 of ESI as an example,the multi-index status of the subject was analyzed in detail,and the publication category,citation of the highly cited papers in domestic universities were analyzed emphatically on journals,publishing institutions and teams,research frontiers and hot spots,etc. In order to provide data and decision-making references for the construction and development of Pharmacology and Toxicology,the domestic research status and frontier hot spots of Pharmacology and Toxicology were summarized.