溴结构域蛋白4的抑制策略及其在肿瘤治疗中的研究进展

Progress of research on inhibition strategy of bromodomain-containing protein 4 and its application in tumor therapy

摘要: 溴结构域蛋白4（bromodomain-containing protein 4，BRD4）是溴结构域和超末端结构域家族中最重要的蛋白，其过度表达与多种肿瘤的发生发展密切相关，成为肿瘤治疗的新靶点。BRD4的抑制策略主要包括BRD4抑制剂和BRD4降解剂，其单独用药或与化学治疗、光热治疗、免疫治疗等治疗手段联合使用均显示出良好的抗肿瘤效果，为肿瘤治疗开辟了新的方向。本文介绍了BRD4的结构及其在肿瘤发生发展中的作用，综述了BRD4的抑制策略、在肿瘤联合治疗中应用以及耐药性的研究进展，为以BRD4为靶点的肿瘤治疗提供理论参考。

Abstract: Bromodomain-containing protein 4 (BRD4), a new target for tumor therapy, is the most important member of the bromodomain and extra-terminal family. The overexpression of BRD4 is associated with genesis and development of various cancers.Used either alone or in combination with other treatments such as chemotherapy, photothermal therapy and immunotherapy, the BRD4 inhibitors or degraders exhibited excellent antitumor effects, providing a new direction in tumor treatment. In this review, the structure and function of BRD4, the inhibition strategies of BRD4, the application in tumor combination therapy and drug resistance are introduced, which provides reference for targeting BRD4 in tumor therapy.