Abstract: Artificial intelligence technologies, particularly the rapidly evolving large language models and generative AI in recent years, are profoundly reshaping the technological landscape of innovative drug research and development. This article systematically reviews the representative achievements made by Chinese researchers in the field of AI-assisted drug design from 2022 to 2025, covering key areas such as target discovery, virtual screening, molecular generation, property prediction, synthetic route planning, and database construction. It highlights China’s rapid progress in both core technological breakthroughs and practical applications of AI-driven drug discovery.