氟苯桂嗪的合成

项曼文, 莫芬珠, 张世春, 赵鸣. 氟苯桂嗪的合成[J]. 中国药科大学学报, 1984, (2): 50-52.

引用本文:

项曼文, 莫芬珠, 张世春, 赵鸣. 氟苯桂嗪的合成[J]. 中国药科大学学报, 1984, (2): 50-52.

Xiang Manwen, Mo Fenzhu, Zhang Shichun, Zhao Ming. SYNTHESIS OF FLUNARIZINE[J]. Journal of China Pharmaceutical University, 1984, (2): 50-52.

Citation:

Xiang Manwen, Mo Fenzhu, Zhang Shichun, Zhao Ming. SYNTHESIS OF FLUNARIZINE[J]. Journal of China Pharmaceutical University, 1984, (2): 50-52.

SYNTHESIS OF FLUNARIZINE

摘要: 氟苯桂嗪(Flunarizine)的化学名为:1-〔双(4-氟苯)甲基〕-4(3-苯基-2-丙烯基)哌嗪。它是一种高效钙拮抗剂本文选用氟苯为原料,经烃化、水解、还原、氯化和缩合等5步反应制得氟苯桂嗪。其化学反应式为

Abstract: Flunarizine, a calcium antagonist, was synthesized from fluobenzene by the reactions of alkylation, hydrolysis, reduction, chlorination and condensation. Its structure was confirmed by 1^HNMR with total yields being about 62%.

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