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呋喃苯胺酸缓释片的溶出试验及其药效学研究[J]. 中国药科大学学报, 1985, (3): 33-36.
引用本文: 呋喃苯胺酸缓释片的溶出试验及其药效学研究[J]. 中国药科大学学报, 1985, (3): 33-36.
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DISSOLUTION TEST IN VITRO AND PHARMACO-DYNAMIC STUDIES ON SUSTAINED RELEASE TABLET OF FUROSEMIDE[J]. Journal of China Pharmaceutical University, 1985, (3): 33-36.
Citation: DISSOLUTION TEST IN VITRO AND PHARMACO-DYNAMIC STUDIES ON SUSTAINED RELEASE TABLET OF FUROSEMIDE[J]. Journal of China Pharmaceutical University, 1985, (3): 33-36.
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呋喃苯胺酸缓释片的溶出试验及其药效学研究

DISSOLUTION TEST IN VITRO AND PHARMACO-DYNAMIC STUDIES ON SUSTAINED RELEASE TABLET OF FUROSEMIDE

    摘要
  • 摘要: 呋喃苯胺酸缓释片在人工胃液中2小时的累积释放率由普通呋喃苯胺酸片的23％降低至4％,而在人工肠液中100％释放时间则由10分钟延长至8小时。药效学试验的结果表明,普通片与缓释片的总利尿量相仿,但缓释片平稳持久地维持较适宜的利尿作用,时间延长至9小时左右,且降低了普通片所致的毒副作用。

     

    Abstract: Based on the theories of orthogonal design and by means of pharma- ceutical technology a sustained release tablet of furosemide was designed. By comparison with conventional tablets,the dissolution ratio in 2 h period in simulated gastric liquid was reduc

     

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