盐酸强力霉素缓释片研究

STUDIES ON SUSTAINED-RELEASE DOXYCYCLINE HYDROCHLORIDE IN TABLETS

摘要: 本文对自制的盐酸强力霉素缓释片进行了研究。测定了体外溶出速率,并用荧光法测定了8名健康受试者单剂量(200mg)口服缓释片(4人)和普通片(4人)(200mg)后的体内血药浓度。实验数据按单室模型并采用TRS-80型计算机和非线性最小二乘法模型嵌合程序进行迭代处理,求得动力学参数。结果表明:缓释片达峰时间较普通片晚2小时,而体内维特有效血浓时间基本相同。9名健康受试者进行的急性胃刺激试验证实:缓释片可减少药物对胃的刺激。

Abstract: This paper deals with the preparation and evaluation of sustained-release Doxycyeline hydrochloride in tablets(S-RDHT)by means of in vitro/invivo tests.The serum levels of healthy adult volunteers following the singleoral dose(200 mg)of both conventional