Michaelis—Menten兼有一级消除动力学模型平均稳态时的一些特性

MATHEMATICS STUDY ON CHARACTERISTICS OF AVERAGE STEADY-STATE FOR DRUGS OBEYING PARALLEL MICHAELIS-MENTEN AND FIRST ORDER KINETICS

摘要: 本文将Rowland等人的二房室模型中的消除过程扩展成米氏兼一级消除过程。据此,推导出达到稳态浓度的时间、血药浓度-时间曲线下面积和生物利用度的公式;进而得到平均清除率和剂量间的关系以及剂量与平均清除率和血浆浓度呈线性关系的结论。

Abstract: The Rowland two-compartment model was extended by replacing parallel Michaelis-Menten and first order kinetics from which the equations for the time to reach the steady-state concentration and bioavailability was derived. The relationship between the aver