6-取代香豆素-3-甲酰胺头孢菌素的合成

SYNTHESIS OF 6-SUBSTITUTED-COUMARIN-3-FORMAMIDO CEPHALOSPORINS

摘要: 本文以6-取代香豆素-3-羧酸与头孢菌素母核缩合,合成了15个未见文献报道的6取代香豆素-3-甲酰胺头孢菌素化合物。其合成方法采用了Vilsmeier试剂法,改进了溶媒及摩尔配比,并进一步探索了分离纯化的过程,以元素分析、IR及NMR确证结构。抑菌试验表明,对某些革兰氏阳性菌具有不同程度的抑菌作用,而某些革兰氏阴性菌的效果则不明显。

Abstract: Fifteen novel derivatives of the 6-substituted-coumarin-3-formamido cephalosporins were obtained by reacting 6-substituted coumarin-3-carboxylic acids with four cephalosporin-nuclears. Vilsmeier reagent method was mainly employed in the procedure of the c