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炎痛喜康软膏的制备及兔透皮吸收[J]. 中国药科大学学报, 1987, (3): 175-178.
引用本文: 炎痛喜康软膏的制备及兔透皮吸收[J]. 中国药科大学学报, 1987, (3): 175-178.
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PREPARATION AND PERCUTANEOUS ABSORPTION OF PIROXICAM OINTMENT BASES[J]. Journal of China Pharmaceutical University, 1987, (3): 175-178.
Citation: PREPARATION AND PERCUTANEOUS ABSORPTION OF PIROXICAM OINTMENT BASES[J]. Journal of China Pharmaceutical University, 1987, (3): 175-178.
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炎痛喜康软膏的制备及兔透皮吸收

PREPARATION AND PERCUTANEOUS ABSORPTION OF PIROXICAM OINTMENT BASES

    摘要
  • 摘要: 为避开炎痛喜康片剂对胃肠道的刺激性,本文研究了炎痛喜康软膏剂的制备及其透皮吸收过程。研制的炎痛喜康软膏剂物理性能较稳定,对家兔皮肤的刺激性很小。炎痛喜康能从软膏基质中缓慢释放,透过家兔皮肤进入血液,在5～28h内保持在有效血药浓度之上。但其体内吸收分数与体外累积释放量之间无显著相关关系。

     

    Abstract: In order to decrease the irritation of Piroxicam tablets to gastrointestinal tract the preparation of Piroxicam ointment bases and their percutaneous absorption were studied. The Piroxicam in the ointment bases was stable and had only very slight irritati

     

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