复方吗啉胍片的非水滴定法

DIFFERENTIAL NON-AQUEOUS TITRATION OF MOROXYDINE HYDROCHLORIDE COMPOUND TABLETS

摘要: 吗啉胍为一抗病毒药物。一般都利用其分子中两个胍基的碱性,采用非水滴定法进行原料或片剂的含量测定。由于片中存在的少量山莨菪碱消耗滴定液,以致干扰测定。但目前往往忽略这项干扰。吗啉胍两个胍基的碱性不同,在水溶液中一分子吗啉胍只与一分子盐酸

Abstract: Moroxydine was determined by non-aqueous titration the titration was carried out in a glacial acetic acid and crystalline violet was taken as an indicator. Mercuric acetate solution was then added and eventually perchloric acid standard solution was emplo