苦参碱类似物的油/水分配系数与药代动力学的关系
RELATIONSHIP BETWEEN THE OIL/WATER PARTITION COEFFICIENT AND THE PHARMACOKINETICS OF MATRINE AND ITS ANALOGUES IN RABBITS
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摘要: Hinderling等研究β-受体阻断剂在人体中药代动力学与结构关系时,发现药物的油水分配性质是药代动力学行为的主要决定因素。苦参碱(Matrine,Ⅰ)及其类似物氧化苦参碱(Oxymatrine,Ⅱ),槐果碱(Sophocarpine,