硝酸甘油贴片的药效学研究
PHARMACODYNAMIC ACTION OF LONG-ACTING TRANSDERMAL DISK OF NITROGLYCERIN
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摘要: 硝酸甘油系目前防治心绞痛的常用药,由于肝脏首过效应,常须舌下给药,药效不过10～30min,长效硝酸酯类如硝酸异山梨醇酯和硝酸戊四醇酯等需大剂量口服,维持药效仅3～4h,效果未臻满意。为了延长药效,有报道制成硝酸甘油软膏及透皮释放膜剂Abstract: The long-acting transdermal disk of nitroglycerin (Nitrogum), containing nitroglycerin 20 mg, was studied on rabbits and volunteers. It showed an excellent systemic hypotensive action on both subjects with stable long-acting effect. Blood pressure was dec
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